Our approach
“The sole purpose of my life has always been an insatiable curiosity about the biological foundations of life, the mechanisms behind the preservation of health and the pathway that leads us to an earlier or later death.”
This statement by Prof. Walter Pierpaoli is one of the best ways to summarise how we conceive, develop and offer innovative treatment solutions and offerings that complement and supplement currently available therapies in physiological and pathological situations that occur throughout an individual’s life.
It is an approach based on the principles of inter-hormonal resynchronisation aimed at preventing and treating those dysfunctions that cause the development of disease and ageing.
There is a close bidirectional interaction between the central structures of the brain (pituitary gland and pineal gland), all the peripheral glands (gonads, adrenal glands, thyroid, etc.) and the thymus (centre of immunity), on which all these relations depend and which the diffuse immune system (particularly in the intestine: lymph nodes and lymphocytes) is derived from.
The immune system is our body’s defence mechanism. It is a highly sophisticated network of cells that detect and destroy viruses, bacteria, precancerous and cancerous cells and other invasive microorganisms that can harm us. As we grow older, the immune system also becomes weaker and less effective. Therefore, the key to preserving health is to maintain a ‘smart’ and well-functioning immune system that can distinguish between ‘good’ and ‘bad’ cells and is able to respond quickly to all the challenges that it meets along the way.
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Topics of interest
Melatonin is a very ancient molecule, which has been involved in the evolution of life on our planet in ancient times, when light and darkness created the ‘life clock’ in a dimension of great mystery and fascination, a molecule with an as yet unexplored potential, especially as an ‘anti-ageing molecule’, i.e., with a function of preventing the ageing of our ‘life clock’ in the pineal gland.
Sleep disorders have a negative impact on the function of the immune system. Therefore, the action of melatonin on sleep can also be considered as an important aid in regulating inflammatory processes and the body’s natural defences, by reducing the time needed to fall asleep and achieving ‘naturally’ more effective sleep.
Clinical studies in this field are revealing glimmers of many other ‘chronobiotic’ actions of melatonin, which potentially have an effect in physiological and pathological situations of extreme interest, such as menopause, macular degeneration, hyperglycaemia, chronic inflammation, etc. We follow and encourage these studies with the utmost interest, convinced that they will provide elements for new therapeutic indications for melatonin.
Our scientific references
Ritmi circadiani e variabili metaboliche
Pubblicato da: Sara Benazzi, Stefania Gorini, Alessandra Feraco & Massimiliano Caprio
Anno: 2021
The Use of Chronobiotics in the Resynchronization of the Sleep–wake Cycle
Pubblicato da: Daniel P Cardinali, Analía M Furio, María P Reyes, Luis I Brusco
Anno: 2006
Role of Melatonin in the Inflammatory Process and its Therapeutic Potential
Pubblicato da: Livia Carrascal, Pedro Nunez-Abades, Antonio Ayala, Mercedes Cano
Anno: 2018
Melatonin as a Hormone: New Physiological and Clinical Insights
Pubblicato da: José Cipolla-Neto, Fernanda Gaspar do Amaral
Anno: 2018
Melatonin as a Chronobiotic with Sleep-promoting Properties
Pubblicato da: Francy Cruz-Sanabria, Claudia Carmassi, Simone Bruno, Andrea Bazzani, Marco Carli, Marco Scarselli, Ugo Faraguna
Anno: 2022
Sleep Health: Reciprocal Regulation of Sleep and Innate Immunity
Pubblicato da: Michael R Irwin, Mark R Opp
Anno: 2017
Melatonin in the eye: Implications for glaucoma
Pubblicato da: Per O Lundmark, S R Pandi-Perumal, V Srinivasan, D P Cardinali, R E Rosenstein
Anno: 2007
Circadian Rhythms of Melatonin Secretion in Peri- and Postmenopausal Women with Insomnia
Pubblicato da: Irina Madaeva, Natalya Semenova, Elena Solodova, Sergey Kolesnikov
Anno: 2017
Changes in nocturnal melatonin secretion in perimenopausal women: Correlation with endogenous estrogen concentrations
Pubblicato da: Y Okatani, N Morioka, A Wakatsuki
Anno: 2000
Age and Chronodisruption in Mouse Heart: Effect of the NLRP3 Inflammasome and Melatonin Therapy
Pubblicato da: Marisol Fernández-Ortiz, Ramy K A Sayed, Yolanda Román-Montoya, María Ángeles Rol de Lama, José Fernández-Martínez, Yolanda Ramírez-Casas, Javier Florido-Ruiz, Iryna Rusanova, Germaine Escames, Darío Acuña-Castroviejo
Anno: 2022
Protective effects of melatonin in experimental free radical-related ocular diseases
Pubblicato da: Andrew W Siu, Maria Maldonado, Marina Sanchez-Hidalgo, Dun-Xian Tan, Russel J Reiter
Anno: 2006
One molecule, many derivatives: A never-ending interaction of melatonin with reactive oxygen and nitrogen species?
Pubblicato da: Dun-Xian Tan,Lucien C. Manchester,Maria P. Terron,Luis J. Flores,Russel J. Reiter
Anno: 2007
Melatonin: Pharmacology, Functions and Therapeutic Benefits
Pubblicato da: Sylvie Tordjman, Sylvie Chokron, Richard Delorme, Annaëlle Charrier, Eric Bellissant, Nemat Jaafari, and Claire Fougerou
Anno: 2017
Our approach is based on professor Walter Pierpaoli’s studies, who dedicated over 50 years to the experimental research in particular about neuro-endocrine-immuno-modulation scope.