In all cases where there is a physiological increase in need for Melatonin and when you wish to contribute to the normal execution of the organism’s functions (for adults, in the case of jet lag, evening and night-time exposure to artificial light, or changes in the sleep wake rhythm). Compensating a Melatonin deficiency helps to maintain balance and synchronization of physiological circadian rhythms and therefore to improve the organism’s wellbeing. The endogenous production of Melatonin is interfered with by external factors that can reduce (and even halt) the secretion of it, and research has shown the close connection between Melatonin and the normal functioning of multiple biological functions and physiological processes.

Current lifestyles require continuous exposure to artificial light (also during dark hours) and devices that emit light radiation (computers, smartphones, etc). This causes an alteration in the normal life rhythms and an increase in stress that, together with imbalanced dietary habits, may cause a reduction in the endogenous production levels of Melatonin.

Supplementing the correct formulation of Melatonin can be of great benefit, aiding the normality of the body’s functions and reducing risk factors of illness or early aging.

Using Melatonin, when taken according to indications, is safe. It is a generally well-tolerated substance without any particular side effects.
No damaging or dangerous side effects have been attributed in twenty years, during which millions of people have taken Melatonin.

The safety and benefits of Melatonin have been confirmed by several studies and scientific publications. Good tolerance of Melatonin has been proven even at high doses in medical-scientific literature: slight side effects have been detected, equivalent (similar) in type and frequency to the ones detected with the placebo.

There are practically no clinically relevant contraindications and undesired effects in the cases where it has been taken according to indications.

Melatonina Zinco Selenio Pierpaoli^®does not create dependency.
On interrupting Melatonin (exogenous administration), the pineal gland once again synthesizes the molecule in physiological quantities.

Taking Melatonina Zinco Selenio Pierpaoli ^® supports the pineal gland’s work, preserving the regulatory function of the systems that determine the health of our physiological processes.
A healthy pineal gland helps these process to stay young and efficient.

In most cases, healthy children and adolescents with a lifestyle that does not affect their biological circadian rhythms (sleep-wake) will not have any Melatonin deficiency. If there are no specific problems and they have a lifestyle that respects biological circadian rhythms, unless otherwise advised by a specialist, children and adolescents do not need Melatonin supplements.

Melatonina Zinco Selenio Pierpaoli^®contributes to reducing the time required to fall asleep, can contribute to improving quality of sleep and consequently lifestyle. A subjective evaluation of one’s own physical and psychophysical conditions may allow you to evaluate the effect of Melatonina Zinco Selenio Pierpaoli ^®considering sleep quality (not necessarily duration), vitality, mood etc.

For a clinical evaluation, a general blood test is required before commencing Melatonina Zinco Selenio Pierpaoli ^®, and then it must be repeated after six months or one year. If you have no illnesses, we recommend measuring FT3, FT4, TSH, Prolactin and Testosterone.

Melatonin is a natural substance released during the night by the pineal gland. It is used to regulate the sleep wake cycle: during the hours of darkness, the epiphysis (the pineal gland) increases Melatonin production, preparing the body for rest; in daytime hours (or exposure to light sources) it reduces production, so that the body stays awake. In a certain sense, Melatonin sends a message to the organism, informing it that it is dark and must get ready to rest. The brain uses the night-time melatonin peak as a signal to inform the organism that it is dark and that the time has therefore come to sleep and rest. The Melatonin peak allows the brain to recognize the integration of Melatonin, thus activating signals to help sleep. In this way, an appropriate Melatonin formulation aids the sensation of sleepiness and the ability to induce and maintain sleep.

Melatonina Zinco Selenio Pierpaoli ^®contributes to the reduction of the time taken to fall asleep. Its formulation has been designed to activate the melatonin peak message, and consequently to favor falling asleep and the ability to remain asleep.

The restorative action of sleep does not depend on its duration, but on its quality. . A normal, restorative sleep is characterized by a non REM phase (with the deep sleep stage) and the REM phase. . During the period of deepest sleep, our organism regenerates (body temperature lowers, metabolism slows down, blood pressure drops, growth hormone increases so that cells can dedicate themselves to self-repairing and multiplying).

If sleep is disturbed by many factors, the deep sleep phase does not take place, REM movements disappear, and symptoms of stress and irritability occur.

It is the quality of sleep that influences our psychophysical well-being, more than the quantity (that can vary greatly). The optimal duration of sleep is an individual condition that varies from person to person. Generally, the need for sleep is reduced with age: after 25 years of age, the deep phase begins to shrink, and at 35/40 years old, it is reduced to 5% of the total duration of sleep. Sleep health influences our hormonal cycle, hormones are produced in variable amounts during the twenty-four hour period. This rhythm (circadian rhythm) can be altered by some factors such as stress, anxiety, illness, jet lag, just to name a few.

Melatonin supports the pineal gland’s action, which regulates the cyclical production of hormones in our organism and plays an important role in regulating circadian cycles and sleep wake rhythms.

Efficacy time may vary depending on the starting condition of your own biological rhythm, and on your lifestyle over the years. To aid the beneficial effects, do not drink coffee or alcohol in the evening, sleep in full darkness, and do not eat during the night.

However, in most cases, the effects of regularly taking Melatonina Zinco Selenio Pierpaoli ^®can be seen within twenty-one days of beginning to use it.

Drinking alcohol inhibits the pineal gland function and the endogenous secretion of Melatonin. Drinking alcohol may influence the effects of Melatonina Zinco Selenio Pierpaoli ^®, reducing the physiological action that the melatonin has on sleep.

The characteristic odor that can sometimes be smelled in Melatonina Zinco Selenio Pierpaoli ^®tablets comes from the characteristics of the natural, bioavailable excipient used in the formulation, that may have a more or less intense odor. This property does not affect the physical-chemical characteristics of the Product.

We use only NON-animal origin ingredients in the Melatonina Zinco Selenio Pierpaoli ^® formulation.

Melatonina Zinco Selenio Pierpaoli ^®does not contain gluten or lactose.