Melatonina zinco selenio Stop sleeping over wrong certainties. Resynchronise yourself Melatonina

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Melatonina Zinco Selenio Pierpaoli®

Average values per daily dose (1 tablet):
Melatonin 1 mg, Zinc 8.7 mg (NRV 87%), Selenium 50 mcg (NRV 90%).

Pack of 60 tablets

Melatonina Zinco Selenio Pierpaoli®:
why this formulation?

Melatonin is a natural molecule mainly synthesized by the pineal gland, that regulates synthesis and the cyclical secretion of our organism’s hormones and is responsible for the night-time melatonin peak.

The night-time melatonin peak starts a sequence of effects that keep the body synchronized with the physiological cyclic nature of hormones and cells. It is during childhood that the production of Melatonin peaks, and then begins to drop gradually until it flattens out and disappears in advanced age.

Melatonin plays an important role in regulating circadian cycles and sleep wake rhythms and is a powerful antioxidant, it has chronobiotic functions and consequently is involved in several physiological activities.

Scientific evidence proves that supplementing with Melatonin can help in certain cases when
the normal circadian rhythms have been altered and sleep is disturbed, including those caused by jet lag, alteration of normal sleep-wake rhythms.

Melatonin has proven to be effective, especially in:

  • contributing to restoring the organism’s natural biological rhythms and alleviating the effects of some circadian rhythm disturbances
  • contributing to the reduction of sleep latency
  • aiding the recovery of the chronobiological alignment of sleep with our internal biological clock
Not just for sleeping, Melatonina Zinco Selenio Pierpaoli® supports health.

Melatonina Zinco Selenio Pierpaoli®:

General Indications


  • Melatonin Pierpaoli contributes to reducing the time required to fall asleep; the beneficial effect is obtained by taking 1 mg of Melatonin just before going to sleep.
  • Melatonin contributes to alleviating the effects of jet lag.
  • Zinc contributes to the normal function of the immune system and the protection of cells from oxidative stress.
  • Selenium contributes to protecting cells from oxidative stress and normal thyroid function.

Original formula created from the scientific observations made in fifty years of research and clinical studies conducted by Professor Walter Pierpaoli and his collaborators, on Melatonin and the pineal gland, and on their close relationship with aging mechanisms.

Melatonin Zinc Selenium Pierpaoli has been developed with the intention of obtaining a melatonin release peak during the night, that helps to re-establish the night-time melatonin peak message and was formulated to meet the need of the body’s physiological functions.

Formulation developed based on clinical trials.

Melatonina, Zinco gluconato, Selenio and Mannitolo.

Recommended: take 1 Melatonina Zinco Selenio Pierpaoli® tablet in the evening, half an hour before going to bed, and preferably between 22.00 and 00.00.

Do not exceed the daily recommended dose. Supplements are not intended to be substitutes for a varied, balanced diet and a healthy lifestyle. Keep out of the reach of children under the age of three years, do not take during pregnancy, store below 25° C and keep away from light sources. Excessive use may cause laxative effects due to the mannitol content.

Safety indications

Taking Melatonin at the recommended doses is safe. Taken according to the indications, Melatonin is generally well tolerated and without particular side effects.
Several scientific publications and studies confirm the safety of Melatonin.

Even in high doses, medical-scientific literature shows a good tolerance of melatonin, with only slight adverse effects that are similar in type and frequency to the ones found with the placebo.
Melatonina Zinco Selenio Pierpaoli®  does not create dependency or assuefaction. On interrupting administration of exogenous Melatonin, the pineal gland starts synthesizing the endogenous molecule again in physiological quantities.

Always consult your doctor beforehand if:

  • you are taking other medication, to make sure that there are no contraindications or possibilities of interactions;
  • use is intended for children and lactating women;
  • supplements are taken for a prolonged period or “chronically”.

Given the lack of studies on this subject, taking Melatonin during pregnancy should be avoided.


If you are taking medication, you must consult with your GP prior to taking Melatonina Zinco Selenio Pierpaoli®, and more generally with any other dietary supplement.

If you have any particular medical conditions or you are following a pharmacological therapy, you must obtain your GP’s opinion as they can evaluate their patients’ medical history and provide the best advice.

Although Melatonin has phamacokinetic and pharmacodynamic characteristics that are potentially modulable by other active principles, to date no interactions have been detected that are the cause for clinical concern.

Undesired Effects

In clinical trials, the most commonly observed adverse events during administration of Melatonin at higher doses than the ones indicated were drowsiness, nausea, headaches and dizziness. However, these undesired effects were also found in subjects who were taking the placebo and the onset of undesired effects did not differ significantly for Melatonin compared to the placebo. To the contrary, in several clinical trials, the percentage of patients who reported an adverse reaction was higher for the placebo than for Melatonin, and therefore the undesired event rate for Melatonin was lower than for the placebo.

Special population groups

As a precaution, we recommend consulting your GP before taking Melatonin if you suffer from severe liver or kidney damage, as to date, a sufficient number of observations to prove the effect of Melatonin in these categories of people has not been reached.

Given the lack of studies on this subject, taking Melatonin should be avoided during pregnancy and in the subsequent breastfeeding phase.

If they have no specific problems, healthy children and adolescents with a lifestyle that does not affect their biological circadian rhythms (sleep-wake) do not usually have a Melatonin deficiency. For this reason, unless otherwise assessed by a specialist, there is no necessity for children and adolescents to take Melatonin supplements.

Prolonged use

The use of Melatonin has been found to be safe in the short and mid term (3-18 months), even at doses higher than the indicated ones, and increasing numbers of trials and clinical data prove the safety of taking it long term.

However, as a precaution, we recommend informing your GP if you should use the supplement for prolonged periods or continuously.

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